IISc Study uncovers Cancer Cell Adaptation During Migration

 

IISc Study uncovers Cancer Cell Adaptation During Migration



    Recent research from the Indian Institute of Science (IISc) sheds light on cancer cell behaviour, published in the Biophysical Journal, and examines how the microenvironment influences cancer cell movement. These dynamics are crucial for tackling metastasis, the process by which cancer spreads.

Types of Ovarian Cancer Cells

    The study focused on two ovarian cancer cell lines – OVCAR-3 and SK-OV-3. OVCAR-3 cells have a rounded shape, while SK-OV-3 cells are elongated. Both types are capable of invading surrounding tissues.

Experimental Setup

    Researchers placed both cell types on surfaces that simulated healthy and diseased tissues. Soft surfaces represented healthy tissue, while stiff surfaces mimicked scarred tissue around tumours. This setup allowed scientists to observe how the cells moved in different conditions.

Movement on Soft Surfaces

    On soft surfaces, both OVCAR-3 and SK-OV-3 cells exhibited slow and random movement. This behaviour resembles how cancer cells might move in healthy tissue, denoting the influence of surface stiffness on their mobility.

    On stiff surfaces, the behaviour of the cells changed . OVCAR-3 cells moved more than SK-OV-3 cells, which was unexpected. The researchers noted that OVCAR-3 cells displayed a unique movement pattern called “slipping.”

Slipping Movement

    Typically, a cell’s movement direction aligns with its shape. However, OVCAR-3 cells did not follow this pattern on stiff surfaces. Instead, they appeared to slide rather than move in a straight line, indicating a complex interaction with their environment.

    The research team aims to delve deeper into the mechanisms driving these movements. They plan to employ advanced methods to study cancer cell behaviour in more intricate 3D environments. This could enhance understanding of ovarian cancer, known for its rapid spread and treatment challenges.


IISc Research
Cancer Cell Adaptation
Cell Migration Mechanisms
Cancer Metastasis Insights
Tumor Cell Plasticity
Cellular Adaptation in Cancer
Metastatic Cancer Study
IISc Cancer Breakthrough
Cancer Research Discoveries
Cell Movement in Tumors


#IIScResearch
#CancerCellAdaptation
#CellMigration
#CancerBiology
#MedicalBreakthrough
#CancerResearch
#TumorMechanisms
#LifeSciences
#BiomedicalInnovation
#HealthResearch
#FutureOfMedicine
#ScientificDiscovery
#CancerAwareness
#IIScStudy
#CellularMechanisms


 Award Registration Link      -   https://germanscientist.com/award-registration/ 
Member Registration Link   -    https://germanscientist.com/member-registration/

For Enquiries: contact@germanscientist.com

Get Connected Here
--------------------------------
--------------------------------

Comments

Post a Comment

Popular posts from this blog

Dengue Surge Linked to Climate Change

Image
  Dengue Surge Linked to Climate Change      Dengue fever cases are at record levels worldwide, with studies linking 19% of the rise to climate change, which is expected to worsen by 2050. Predictions indicate a potential 40-60% rise in cases, with some areas facing increases of 150-200%. Current Global Context      Recently, nearly 12 million dengue cases were reported in the Americas. This marks an important rise from 4.6 million in 2023. Locally acquired infections have emerged in California and Florida. India is also experiencing a surge in cases. Research Findings      Researchers from Stanford and Harvard conducted a study on dengue incidence. They analyzed data from 21 countries in Asia and the Americas. The results show a direct correlation between rising temperatures and increasing dengue infections.      Dengue can cause mild to severe symptoms. Severe cases may lead to bleeding and shock. There are no specif...
Read more

Clean Ganga Mission to Start Dolphin Ambulance

Image
  Clean Ganga Mission to Start Dolphin Ambulance      The National Mission for Clean Ganga (NMCG) is actively promoting conservation efforts and targeting the Ganga River’s biodiversity. They focus particularly on endangered species like the Ganga Dolphin . Recent developments include the introduction of a Dolphin Ambulance. This vehicle will aid in rescuing injured dolphins, which are crucial to the river’s ecosystem. Dolphin Ambulance Initiative      The Dolphin Ambulance project is titled Advancing Rescue System for the Protection of Stranded Ganges River Dolphins, which has a budget of Rs 1 crore. The ambulance will provide immediate care to injured dolphins. The initiative aims to enhance public awareness about dolphin conservation. Training will be provided to local communities. This training focuses on the effective management of dolphin-related issues. Additional Conservation Projects      NMCG has approved several other proje...
Read more

Operation Dronagiri

Image
  Operation Dronagiri      Professor Abhay Karandikar, Secretary of the Department of Science and Technology , introduced Operation Dronagiri, which aligns with the National Geospatial Policy 2022. It aims to showcase geospatial technologies to enhance citizens’ quality of life and streamline business operations. Objectives of Operation Dronagiri      Operation Dronagiri focuses on three key sectors: Agriculture, Livelihoods, and Logistics and Transport. The initiative will be implemented in five states: Uttar Pradesh, Haryana, Assam, Andhra Pradesh, and Maharashtra. Pilot projects will demonstrate the integration of geospatial data in these sectors.      The project will involve various stakeholders, including government departments, industries, corporates, and startups. This collaborative approach aims to create a robust foundation for a nationwide rollout. Engagement from the private sector is crucial for the project’s success. In...
Read more